PXD030545 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | C11orf94/Frey is a key regulator for male fertility by controlling sperm fusion complex assembly |
Description | The sperm fusion complex built around the Izumo1 protein is the key male factor for mediation of gamete fusion. Loss of several complex members leads to male infertility. Here, we provide a detailed characterisation of the C11orf94/Frey protein which acts as central chaperone for assembly of the sperm fusion complex. By retaining Izumo1 in the endoplasmic reticulum, C11orf94 is essentially required to facilitate the recruitment of Izumo1-interacting proteins into the sperm fusion complex. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:34:49.336.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD030545 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Marc Gentzel |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-12-20 11:06:35 | ID requested | |
1 | 2022-10-14 10:47:45 | announced | |
⏵ 2 | 2023-11-14 08:34:50 | announced | 2023-11-14: Updated project metadata. |
Publication List
10.6019/PXD030545; |
Contreras W, Wieseh, ö, fer C, Schreier D, Leinung N, Peche P, Wennemuth G, Gentzel M, Schr, ö, der B, Mentrup T, C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly. Sci Adv, 8(32):eabo6049(2022) [pubmed] |
Keyword List
submitter keyword: AP-MS, Gamete Fusion, label-free quantitative Co-IP,Male infertility, Mouse, Izumo1, C11orf94/Frey, LC-MS/MS |
Contact List
Dr. Torben Mentrup |
contact affiliation | Institute of Physiological Chemistry, Technische Universität Dresden, Dresden, Germany Fetscherstr. 74 01307 Dresden |
contact email | torben.mentrup@tu-dresden.de |
lab head | |
Marc Gentzel |
contact affiliation | Molecular Analysis - Mass Spectrometry, Center for Molecular and Cellular Bioengineering (CMCB), TU Dresden |
contact email | marc.gentzel@tu-dresden.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030545
- Label: PRIDE project
- Name: C11orf94/Frey is a key regulator for male fertility by controlling sperm fusion complex assembly