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PXD030545

PXD030545 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleC11orf94/Frey is a key regulator for male fertility by controlling sperm fusion complex assembly
DescriptionThe sperm fusion complex built around the Izumo1 protein is the key male factor for mediation of gamete fusion. Loss of several complex members leads to male infertility. Here, we provide a detailed characterisation of the C11orf94/Frey protein which acts as central chaperone for assembly of the sperm fusion complex. By retaining Izumo1 in the endoplasmic reticulum, C11orf94 is essentially required to facilitate the recruitment of Izumo1-interacting proteins into the sperm fusion complex.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:34:49.336.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD030545
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMarc Gentzel
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-12-20 11:06:35ID requested
12022-10-14 10:47:45announced
22023-11-14 08:34:50announced2023-11-14: Updated project metadata.
Publication List
10.6019/PXD030545;
Contreras W, Wieseh, ö, fer C, Schreier D, Leinung N, Peche P, Wennemuth G, Gentzel M, Schr, ö, der B, Mentrup T, C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly. Sci Adv, 8(32):eabo6049(2022) [pubmed]
Keyword List
submitter keyword: AP-MS, Gamete Fusion, label-free quantitative Co-IP,Male infertility, Mouse, Izumo1, C11orf94/Frey, LC-MS/MS
Contact List
Dr. Torben Mentrup
contact affiliationInstitute of Physiological Chemistry, Technische Universität Dresden, Dresden, Germany Fetscherstr. 74 01307 Dresden
contact emailtorben.mentrup@tu-dresden.de
lab head
Marc Gentzel
contact affiliationMolecular Analysis - Mass Spectrometry, Center for Molecular and Cellular Bioengineering (CMCB), TU Dresden
contact emailmarc.gentzel@tu-dresden.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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