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PXD030390-1

PXD030390 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Signature for Detection of High Grade Ovarian Cancer in germline BRCA mutation carriers
DescriptionThere are currently no screening methods for high grade ovarian cancer (HGOC) that guarantee effective early detection for high risk women such as germline BRCA mutation carriers. Therefore, the standard-of-care remains risk reducing salpingo-oophorectomy (RRSO) around age 40. Proximal liquid biopsy has been shown to be a promising source of biomarkers, but sensitivity has not yet qualified for clinical implementation. We report the discriminant performance of a novel proteomic classifier for detection of HGOC in high-risk population, and the safety and feasibility of simplified utero-tubal lavage (UtL) as a method for sampling proximal liquid biopsy.The training set included 93 women with high-risk for HGOC (BRCA1 and BRCA2 mutation carriers), including: 16 HGOC patients and 77 asymptomatic women, who donated UtL liquid biopsies, in 3 Israeli medical centers (Biomarkers for Early Detection of Ovarian Cancer Using Uterine Lavage (BEDOCA); ClinicalTrials.gov Identifier: NCT03150121). The proteome of the microvesicle fraction of the samples was profiled by mass spectrometry and a classifier was developed using logistic regression. An independent cohort of 104 BRCA mutation carriers was used as validation. Safety information was collected for all women who opted to UtL in a clinic setting.
HostingRepositoryPRIDE
AnnounceDate2022-09-13
AnnouncementXMLSubmission_2022-09-13_05:15:20.832.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTamar Geiger
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-12-14 07:59:51ID requested
12022-09-13 05:15:21announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Ovarian cancer, biomarkers, liquid biopsies, BRCA, uterine lavage
Contact List
Tami Geiger
contact affiliationWeizmann Institute of Science
contact emailtami.geiger@weizmann.ac.il
lab head
Tamar Geiger
contact affiliationWeizmann Institute of Science
contact emailgeiger@tauex.tau.ac.il
dataset submitter
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Dataset FTP location
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