PXD030347

PXD030347 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Integrated metabolomics and proteomics analysis of urine in a mouse model of Posttraumatic stress disorder
Description	Posttraumatic stress disorder (PTSD) is a serious stress disorder that occurs in individuals who have experienced major events. The underlying pathological mechanisms of PTSD are complex, and the related predisposing factors are still not fully understood. In this study, the proteomics and metabolomics characteristics between male the C57BL/6 normal group mice and a PTSD mice model group were analyzed using label-free quantitative proteomics and untargeted metabolomics. Differential expression analysis showed that 27 proteins were significantly differentially expressed between the two groups. Bioinformatics analysis revealed that the differentiated proteins were mostly enriched in: small molecule binding, transporter activity, extracellular region, extracellular space, endopeptidase activity, zymogen activation, hydrolase activity, proteolysis, peptidase activity, sodium channel regulator activity.
HostingRepository	iProX
AnnounceDate	2021-12-13
AnnouncementXML	Submission_2021-12-12_21:36:38.179.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daxue Zhou
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-12 21:36:28	ID requested
⏵ 1	2021-12-12 21:36:39	announced

Publication List

Bodea SV, Westmeyer GG, Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience. Front Neurosci, 15():655247(2021) [pubmed]

Bodea SV, Westmeyer GG, Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience. Front Neurosci, 15():655247(2021) [pubmed]

Keyword List

submitter keyword: Posttraumatic stress disorder (PTSD), PTSD model, Urine, Proteomics, Mice

submitter keyword: Posttraumatic stress disorder (PTSD), PTSD model, Urine, Proteomics, Mice

Contact List

Yi Huang
contact affiliation	Biomedical Analysis Center, Army Medical University
contact email	huangyi@tmmu.edu.cn
lab head
Daxue Zhou
contact affiliation	Biomedical Analysis Center, Army Medical University
contact email	zhoudaxue2008@126.com
dataset submitter

Full Dataset Link List

iProX dataset URI

iProX dataset URI