PXD029960-1

PXD029960 is an original dataset announced via ProteomeXchange.

Title	Investigating the interactome of TurboID-tagged RABGAP1L in the presence or absence of IFNa2 by proximity labeling proteomics
Description	RABGAP1L, a Tre2/Bub2/Cdc16 (TBC) domain-containing protein involved in the regulation of small membrane-bound GTPases, was identified in an RNAi screen to robustly potentiate the antiviral action of Interferon (IFN) against influenza A viruses (IAVs). Functional studies revealed that the catalytically active TBC domain of RABGAP1L promotes antiviral activity. By using proximity-labeling approaches, the aim was to investigate the protein’s interactome and thereby identify its possible role in existing signaling pathways.
HostingRepository	PRIDE
AnnounceDate	2022-04-07
AnnouncementXML	Submission_2022-04-07_07:09:43.105.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sonja Fernbach
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-11-26 04:11:52	ID requested
⏵ 1	2022-04-07 07:09:43	announced

Dataset with its publication pending

submitter keyword: TurboID, proximity labeling, interactome, RABGAP1L

Benjamin Geoffrey Hale
contact affiliation	University of Zurich, Institute of Medical Virology, Switzerland
contact email	hale.ben@virology.uzh.ch
lab head
Sonja Fernbach
contact affiliation	University of Zurich, Institute of Medical Virology
contact email	harms.sonja@virology.uzh.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD029960

PRIDE project URI

• PRIDE
  1. PXD029960
     1. Label: PRIDE project
     2. Name: Investigating the interactome of TurboID-tagged RABGAP1L in the presence or absence of IFNa2 by proximity labeling proteomics