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PXD029635-1

PXD029635 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics investigations of potential protein biomarkers in sera of rabbits infected with Schistosoma japonicum
DescriptionSchistosomiasis is a chronic parasitic disease that continues to be a pressing public health problem in many developing countries. The primary pathological damage from the disease is granuloma and fibrosis caused by egg aggregation, and early treatment can effectively prevent the occurrence of liver fibrosis. Therefore, it is very important to identify biomarkers that can be used for early diagnosis of Schistosoma japonicum infection. In this study, a label-free proteomics method was performed to observe the alteration of proteins before infection, 1 week, and 6 weeks after infection, as well as 5 weeks and 7 weeks after treatment. A total of 10 proteins derived from S. japonicum and 242 host-derived proteins were identified and quantified as significantly changed. Temporal analysis was carried out to further analyze potential biomarkers with coherent changes during infection and treatment. The results revealed biological process changes in serum proteins compared to infection and treatment groups, which implicated receptor-mediated endocytosis, inflammatory response, and acute-phase response such as Mannan binding lectin serine peptidase 1, immunoglobulin, and phosphoglycerate mutase. These findings offer guidance for in-depth analysis of potential biomarkers of Schistosomiasis, host protein, and early diagnosis of S. japonica and its pathogenesis.
HostingRepositoryPRIDE
AnnounceDate2021-12-20
AnnouncementXMLSubmission_2021-12-20_11:48:25.974.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNian-Nian Bi
SpeciesList scientific name: Oryctolagus cuniculus; NCBI TaxID: 9986;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-11-09 06:07:57ID requested
12021-12-20 11:48:26announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Schistosoma japonicum, proteomics, label free, biomarker, bioinformatics
Contact List
Kun Yang
contact affiliationKey Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Pre-vention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, 117 Meiyuan Yangxiang, Wuxi 214064, Jiangsu, China.
contact emailyangkun@jipd.com
lab head
Nian-Nian Bi
contact affiliationNanjing Medical University
contact emailmylmbnn@163.com
dataset submitter
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Dataset FTP location
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