PXD029631 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative proteomic analysis of keloid scars and normal skin tissues |
Description | Keloid scars is a pathologic fibro-proliferative disorders of the skin, which exhibit abnormal phenotypes including fibroblasts proliferation and collagen deposits. There have been several treatments of keloids including conventional surgical therapies and adjuvant therapies, but a high recurrence rate of keloids was also observed after treatment. Quantitative proteomics approach has been proved an efficient approach to investigate pathological mechanism and novel biomarkers. In this study, we present a label-free quantitative proteomics analysis to explore differential protein expression profiles in normal skin and keloid scar tissues based on nano-liquid chromatography and tandem mass spectrometry (Nano-LC–MS/MS). The study results displayed a more comprehensive keloid protein expression landscape and provided novel pathological insight of keloid. |
HostingRepository | PRIDE |
AnnounceDate | 2023-03-11 |
AnnouncementXML | Submission_2023-03-10_20:36:49.459.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | JiaMi |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-11-09 06:07:39 | ID requested | |
⏵ 1 | 2023-03-10 20:36:50 | announced | |
2 | 2023-11-14 08:37:09 | announced | 2023-11-14: Updated project metadata. |
Publication List
Liu J, Yang C, Zhang H, Hu W, Bergquist J, Wang H, Deng T, Yang X, Zhang C, Zhu Y, Chi X, Mi J, Wang Y, Quantitative proteomics approach reveals novel biomarkers and pathological mechanism of keloid. Proteomics Clin Appl, 16(4):e2100127(2022) [pubmed] |
Keyword List
submitter keyword: keloids, proteomics, endoplasmic reticulum, LC-MS/MS,, bioinformatics |
Contact List
Quantitative proteomic analysis of keloid scars and normal skintissues |
contact affiliation | Precision Medicine Research Center, School of Pharmacy, Binzhou Medical University, Yantai, Shandong Province, 264003, PR China. |
contact email | jia.mi@bzmc.edu.cn |
lab head | |
JiaMi |
contact affiliation | Binzhou Medical University |
contact email | jia.mi@bzmc.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029631
- Label: PRIDE project
- Name: Quantitative proteomic analysis of keloid scars and normal skin tissues