PXD029567 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Increased soluble HLA in COVID-19 present a disease-related, diverse immunopeptidome associated with T cell immunity |
Description | HLA-presented antigenic peptides are central components of T cell-based immunity in infectious disease. Beside HLA molecules on cell surfaces, soluble HLA molecules (sHLA) are released in the blood suggested to impact cellular immune responses. We demonstrated that sHLA levels were significantly increased in COVID-19 patients and convalescent individuals compared to a control cohort and positively correlated with SARS CoV-2-directed cellular immunity. Of note, patients with severe courses of COVID-19 showed reduced sHLA levels. Mass spectrometry-based characterization of sHLA-bound antigenic peptides, the so called soluble immunopeptidome, revealed a COVID-19-associated increased diversity of HLA-presented peptides and identified a naturally presented SARS-CoV-2-derived peptide from the viral nucleoprotein in the plasma of COVID-19 patients. Interestingly, sHLA serum levels directly correlated with the diversity of the soluble immunopeptidome. Together, these findings suggest an inflammation-driven release of sHLA in COVID-19, directly influencing the diversity of the soluble immunopeptidome with implications for SARS-CoV-2-directed T cell-based immunity and disease outcome. |
HostingRepository | PRIDE |
AnnounceDate | 2022-11-23 |
AnnouncementXML | Submission_2022-11-23_08:03:54.798.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | AnnikaNelde |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-11-04 10:17:10 | ID requested | |
⏵ 1 | 2022-11-23 08:03:55 | announced | |
2 | 2023-11-14 08:53:56 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
ProteomeXchange project tag: Covid-19 |
submitter keyword: COVID-19, immunopeptidome, soluble HLA |
Contact List
Juliane S.Walz |
contact affiliation | Clinical Collaboration Unit Translational Immunology, University Hospital Tübingen, Tübingen, Germany |
contact email | juliane.walz@med.uni-tuebingen.de |
lab head | |
AnnikaNelde |
contact affiliation | Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Germany |
contact email | annika.nelde@uni-tuebingen.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029567
- Label: PRIDE project
- Name: Increased soluble HLA in COVID-19 present a disease-related, diverse immunopeptidome associated with T cell immunity