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PXD029291-2

PXD029291 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleN1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
DescriptionThe COVID mRNA vaccines utilize the modified nucleobase N1-methylpseudouridine, in place of canonical uridine, to improve immunogenicity and protein yield. However, relatively few studies have investigated the effect of modified nucleobases on the fidelity of protein translation. Given the interest in the COVID mRNA vaccines, we sought to investigate how N1-methylpseudouridine (and the related modification pseudouridine) is read by ribosomes.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:55:07.280.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD029291
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterKyusik Kim
SpeciesList scientific name: Severe acute respiratory syndrome coronavirus 2; NCBI TaxID: 2697049;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-10-22 06:57:13ID requested
12022-08-18 12:41:58announced
22023-11-14 08:55:08announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
ProteomeXchange project tag: Sars-cov-2, Covid-19
submitter keyword: SARS-CoV-2, N1-methylpseudouridine, ribosome, decoding, fidelity, COVID-19, mRNA vaccine, translation
Contact List
Hani Zaher
contact affiliationDepartment of Biology, Washington University in St. Louis
contact emailhzaher@wustl.edu
lab head
Kyusik Kim
contact affiliationWashington University in St. Louis
contact emailkyusikkim@wustl.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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