PXD028979

PXD028979 is an original dataset announced via ProteomeXchange.

Title	Proteomic and phosphoproteomic profilings in fibroblasts of 11 common mammalian species
Description	A central goal of modern biology is to understand the molecular basis of phenotype evolution between species. Previously, the evolutionary profiling at the molecular level has been largely limited to the nucleotide level. Nevertheless, the genotype is translated to proteotype through comprehensive and gene-specific post-transcriptional regulations. Harnessing recently emerged consistent proteomic quantification methods, we here investigate the co-evolution processes across the transcriptomic, proteomic, and phosphoproteomic layers in skin fibroblasts from 11 common mammalian species. Altogether, we have generated a multi-species, multi-omics resource, the analysis of which significantly facilitates the understanding of gene expression, proteotype co-evolution, and biodiversity in mammals.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:53:53.224.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenxue Li
SpeciesList	scientific name: Oryctolagus cuniculus (Rabbit); NCBI TaxID: 9986; scientific name: Macaca mulatta (Rhesus macaque); NCBI TaxID: 9544; scientific name: Ovis aries; NCBI TaxID: 9940; scientific name: Bos taurus (Bovine); NCBI TaxID: 9913; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; scientific name: Monodelphis domestica; NCBI TaxID: 13616; scientific name: Felis catus (Cat) (Felis silvestris catus); NCBI TaxID: 9685; scientific name: Canis lupus; NCBI TaxID: 9612; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Equus caballus (Horse); NCBI TaxID: 9796; scientific name: Sus scrofa (Pig); NCBI TaxID: 9823;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-07 00:28:37	ID requested
1	2022-09-21 21:51:07	announced
⏵ 2	2023-11-14 08:53:54	announced	2023-11-14: Updated project metadata.

Ba Q, Hei Y, Dighe A, Li W, Maziarz J, Pak I, Wang S, Wagner GP, Liu Y, Proteotype coevolution and quantitative diversity across 11 mammalian species. Sci Adv, 8(36):eabn0756(2022) [pubmed]

submitter keyword: Phosphoproteomics, DIA-MS, multiple species, quantitative proteomics

Yansheng Liu
contact affiliation	Department of Pharmacology, Yale University School of Medicine
contact email	yansheng.liu@yale.edu
lab head
Wenxue Li
contact affiliation	Yale University
contact email	wenxue.li@yale.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/09/PXD028979

PRIDE project URI

• PRIDE
  1. PXD028979
     1. Label: PRIDE project
     2. Name: Proteomic and phosphoproteomic profilings in fibroblasts of 11 common mammalian species