PXD028885 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Circulating Microvesicles and Exosomes in Small Cell Lung Cancer by Quantitative Proteomics |
Description | Early detection of small cell lung cancer crucially demands highly reliable markers. Growing evidence suggests that extracellular vesicles carry tumor cell-specific cargo suitable as protein markers in cancer. Therefore, we isolated plasma-derived exosomes from newly diagnosed small cell lung cancer patients and investigated proteome dynamics of these exosomes aiming at improving the detection of small cell lung cancer. A total of 1,016 proteins were initially identified. After data processing and statistical analysis, several proteins were found to be differentially expressed in comparing small cell lung cancer patients and healthy individuals, indicating that circulating exosomes may encompass specific proteins with potential diagnostic attributes for small cell lung cancer. Furthermore, our data may indicate a novel tumor-suppressing role of blood coagulation and involvement of complement activation in small cell lung cancer pathogenesis. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-27 |
AnnouncementXML | Submission_2022-05-27_05:15:57.719.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Bent Honoré |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-10-01 09:30:11 | ID requested | |
⏵ 1 | 2022-05-27 05:15:58 | announced | |
Publication List
Pedersen S, Jensen KP, Honor, é B, Kristensen SR, Pedersen CH, Szejniuk WM, Maltesen RG, Falkmer U, Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics. Clin Proteomics, 19(1):2(2022) [pubmed] |
Keyword List
submitter keyword: Human, Plasma, Extracellular vesicles, LC-MS/MS |
Contact List
Bent Honoré |
contact affiliation | Aarhus University |
contact email | bh@biomed.au.dk |
lab head | |
Bent Honoré |
contact affiliation | Aarhus University |
contact email | bent.honore@dadlnet.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD028885 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD028885
- Label: PRIDE project
- Name: Circulating Microvesicles and Exosomes in Small Cell Lung Cancer by Quantitative Proteomics