PXD028885

PXD028885 is an original dataset announced via ProteomeXchange.

Title	Circulating Microvesicles and Exosomes in Small Cell Lung Cancer by Quantitative Proteomics
Description	Early detection of small cell lung cancer crucially demands highly reliable markers. Growing evidence suggests that extracellular vesicles carry tumor cell-specific cargo suitable as protein markers in cancer. Therefore, we isolated plasma-derived exosomes from newly diagnosed small cell lung cancer patients and investigated proteome dynamics of these exosomes aiming at improving the detection of small cell lung cancer. A total of 1,016 proteins were initially identified. After data processing and statistical analysis, several proteins were found to be differentially expressed in comparing small cell lung cancer patients and healthy individuals, indicating that circulating exosomes may encompass specific proteins with potential diagnostic attributes for small cell lung cancer. Furthermore, our data may indicate a novel tumor-suppressing role of blood coagulation and involvement of complement activation in small cell lung cancer pathogenesis.
HostingRepository	PRIDE
AnnounceDate	2022-05-27
AnnouncementXML	Submission_2022-05-27_05:15:57.719.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bent Honoré
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-01 09:30:11	ID requested
⏵ 1	2022-05-27 05:15:58	announced

Pedersen S, Jensen KP, Honor, é B, Kristensen SR, Pedersen CH, Szejniuk WM, Maltesen RG, Falkmer U, Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics. Clin Proteomics, 19(1):2(2022) [pubmed]

submitter keyword: Human, Plasma, Extracellular vesicles, LC-MS/MS

Bent Honoré
contact affiliation	Aarhus University
contact email	bh@biomed.au.dk
lab head
Bent Honoré
contact affiliation	Aarhus University
contact email	bent.honore@dadlnet.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD028885

PRIDE project URI

• PRIDE
  1. PXD028885
     1. Label: PRIDE project
     2. Name: Circulating Microvesicles and Exosomes in Small Cell Lung Cancer by Quantitative Proteomics