PXD028622-1
PXD028622 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Toxicokinetics of arenobufagin and its cardiotoxicity mechanism exploration based on lipidomics and proteomics approaches in rats |
Description | In this study, the hearts used for proteomics analysis were obtained from rats randomly divided into three groups (6 rats in each group): a control group (a mixture of propanediol and sodium chloride solution), a low-dose ArBu group (ArBu suspension 60 mg/kg) and a high-dose ArBu group (ArBu suspension 120 mg/kg). After a 12 h fast, the rats were intragastrically administered with or without arenobufagin suspension for 2 h. Proteomics and PRM analysis were used for the exploration of cardiotoxicity mechanism. |
HostingRepository | iProX |
AnnounceDate | 2021-09-17 |
AnnouncementXML | Submission_2021-09-18_00:35:17.018.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Lingyu Han |
SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-09-18 00:34:39 | ID requested | |
⏵ 1 | 2021-09-18 00:35:17 | announced | |
2 | 2022-10-19 20:41:30 | announced | 2022-10-20: Update publication information. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: arenobufagin, cardiotoxicity, toxicokinetic, lipidomics, proteomics |
Contact List
Haiyu Zhao | |
---|---|
contact affiliation | China Academy of Chinese Medical Sciences |
contact email | hyzhao@icmm.ac.cn |
lab head | |
Lingyu Han | |
contact affiliation | Tsinghua University |
contact email | 376693698@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |