PXD028622

PXD028622 is an original dataset announced via ProteomeXchange.

Title	Toxicokinetics of arenobufagin and its cardiotoxicity mechanism exploration based on lipidomics and proteomics approaches in rats
Description	In this study, the hearts used for proteomics analysis were obtained from rats randomly divided into three groups (6 rats in each group): a control group (a mixture of propanediol and sodium chloride solution), a low-dose ArBu group (ArBu suspension 60 mg/kg) and a high-dose ArBu group (ArBu suspension 120 mg/kg). After a 12 h fast, the rats were intragastrically administered with or without arenobufagin suspension for 2 h. Proteomics and PRM analysis were used for the exploration of cardiotoxicity mechanism.
HostingRepository	iProX
AnnounceDate	2021-09-17
AnnouncementXML	Submission_2022-10-19_20:41:29.958.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lingyu Han
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-18 00:34:39	ID requested
1	2021-09-18 00:35:17	announced
⏵ 2	2022-10-19 20:41:30	announced	2022-10-20: Update publication information.

Zhao L, Han L, Wei X, Zhou Y, Zhang Y, Si N, Wang H, Yang J, Bian B, Zhao H, Toxicokinetics of Arenobufagin and its Cardiotoxicity Mechanism Exploration Based on Lipidomics and Proteomics Approaches in Rats. Front Pharmacol, 12():780016(2021) [pubmed]

submitter keyword: arenobufagin, cardiotoxicity, toxicokinetic, lipidomics, proteomics

Haiyu Zhao
contact affiliation	China Academy of Chinese Medical Sciences
contact email	hyzhao@icmm.ac.cn
lab head
Lingyu Han
contact affiliation	Tsinghua University
contact email	376693698@qq.com
dataset submitter

iProX dataset URI