PXD028488-1

PXD028488 is an original dataset announced via ProteomeXchange.

Title	Discovery of Signature Cyclic Immonium Ion for Lactyllysine Reveals Widespread and Functional Lactylation on Non-histone Proteins
Description	Here we employed a non-enzymatic chemical labeling approach to introduce lactylation on lysine residues of model peptides and proteins. Tandem MS acquisition of lactylated peptide carriers on different MS platforms unequivocally led us to note an intense peak corresponding to the “cyclic” immonium ion of lactyllysine that is generated from the “linear” immonium ion upon the loss of NH3. The cycIm ion provides superior sensitivity and specificity as a lactylation marker than the linIm ion. Together, the ability to confidently identify protein lactylation empowers mapping the landscape of human lactylation proteome and fosters ensuing investigation into the regulatory mechanisms of lactylation when our understanding to this newly discovered PTM is still during its infancy.
HostingRepository	iProX
AnnounceDate	2021-09-15
AnnouncementXML	Submission_2022-06-09_05:06:27.548.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ning Wan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	lactic acid
Instrument	Orbitrap Eclipse; SYNAPT G2-Si; timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2021-09-15 19:54:57	ID requested
⏵ 1	2022-06-09 05:06:27	announced
2	2022-06-28 18:58:52	announced	2022-06-29: Update publication information.
3	2022-06-28 19:01:20	announced	2022-06-29: Update publication information. 2022-06-29: Update information.

Dataset with its publication pending

submitter keyword: Human, Orbitrap, Waters synapt G2

Hui Ye
contact affiliation	China Pharmaceutical University
contact email	cpuyehui@cpu.edu.cn
lab head
Ning Wan
contact affiliation	China Pharmaceutical University
contact email	wan_ning95@126.com
dataset submitter

iProX dataset URI