PXD028488
PXD028488 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome |
| Description | Here we employed a non-enzymatic chemical labeling approach to introduce lactylation on lysine residues of model peptides and proteins. Tandem MS acquisition of lactylated peptide carriers on different MS platforms unequivocally led us to note an intense peak corresponding to the “cyclic” immonium ion of lactyllysine that is generated from the “linear” immonium ion upon the loss of NH3. The cycIm ion provides superior sensitivity and specificity as a lactylation marker than the linIm ion. Together, the ability to confidently identify protein lactylation empowers mapping the landscape of human lactylation proteome and fosters ensuing investigation into the regulatory mechanisms of lactylation when our understanding to this newly discovered PTM is still during its infancy. |
| HostingRepository | iProX |
| AnnounceDate | 2021-09-15 |
| AnnouncementXML | Submission_2022-06-28_19:01:19.513.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ning Wan |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | lactic acid |
| Instrument | Orbitrap Eclipse; SYNAPT G2-Si; timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2021-09-15 19:54:57 | ID requested | |
| 1 | 2022-06-09 05:06:27 | announced | |
| 2 | 2022-06-28 18:58:52 | announced | 2022-06-29: Update publication information. |
| ⏵ 3 | 2022-06-28 19:01:20 | announced | 2022-06-29: Update publication information. 2022-06-29: Update information. |
Publication List
| Wan N, Wang N, Yu S, Zhang H, Tang S, Wang D, Lu W, Li H, Delafield DG, Kong Y, Wang X, Shao C, Lv L, Wang G, Tan R, Wang N, Hao H, Ye H, Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome. Nat Methods, 19(7):854-864(2022) [pubmed] |
Keyword List
| submitter keyword: Human, Orbitrap, Waters synapt G2 |
Contact List
| Hui Ye | |
|---|---|
| contact affiliation | China Pharmaceutical University |
| contact email | cpuyehui@cpu.edu.cn |
| lab head | |
| Ning Wan | |
| contact affiliation | China Pharmaceutical University |
| contact email | wan_ning95@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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