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PXD027853-1

PXD027853 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTriazine pyridine Chemistry for Protein Labelling on Tyrosine.
DescriptionChemoselective reactions allowing for amino acid-specific modification are essential for protein bioconjugation and covalent drug development. Apart from Lysine and Cysteine with superior nucleophilic side chains, other amino acid-selective reactions are also needed but not well developed. Herein, we report the development of the biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine-specific labelling under physiological conditions and profiling in whole proteome. TPC exhibited high tyrosine chemoselectivity in biological systems, displayed potentials in tyrosine-guided protein labelling, and had biocompatibility in living cells. The development of TPC based tyrosine labelling agents would offer additional tools in native protein chemical modification.
HostingRepositoryMassIVE
AnnounceDate2021-08-10
AnnouncementXMLSubmission_2021-08-10_23:59:09.935.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZhang Qing
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListunknown modification
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-10 23:47:53ID requested
12021-08-10 23:59:10announced
Publication List
no publication
Keyword List
submitter keyword: Tyrosine labeling, Triazine-pyridine chemistry
Contact List
Prof. Xuechen Li
contact affiliationThe University of Hong Kong
contact emailxuechenl@hku.hk
lab head
Zhang Qing
contact affiliationThe University of Hong Kong
contact emailzhangqing7864@163.com
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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