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PXD027780-2

PXD027780 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleConnecting multiple microenvironment proteomes uncovers the biology in head and neck cancer
DescriptionThe poor prognosis of head and neck cancer (HNC) is associated with metastasis within the lymph nodes (LNs). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN-negative or -positive tissues, saliva, and blood cells, reveals insights into the biology and potential metastasis biomarkers that may assist in clinical decision-making. Protein profiles are strictly associated with immune modulation across datasets, and this provides the basis for investigating immune markers associated with metastasis. The proteome of LN metastatic cells recapitulates the proteome of the primary tumor sites. Conversely, the LN microenvironment proteome highlights the candidate prognostic markers. By integrating prioritized peptide, protein, and transcript levels with machine learning models, we identified nodal metastasis signatures in blood and saliva. We present a proteomic characterization wiring multiple sites in HNC, thus providing a promising basis for understanding tumoral biology and identifying metastasis-associated signatures.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:53:27.767.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAdriana Franco Paes Leme
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-06 03:44:53ID requested
12022-11-21 05:34:56announced
22023-11-14 08:53:28announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Machine Learning,Head and Neck Squamous Cell Carcinoma, Buffy Coat, Saliva, Mouth Neoplasms, Proteomics, Lymph Node Metastasis, Prognosis, Immune System, Biomarkers
Contact List
Adriana Franco Paes Leme
contact affiliationLaboratório Nacional de Biociências - LNBio; Centro Nacional de Pesquisa em Energia e Materiais - CNPEM; Campinas; SP; 13083-100; Brazil
contact emailadriana.paesleme@lnbio.cnpem.br
lab head
Adriana Franco Paes Leme
contact affiliationCNPEM
contact emailadriana.paesleme@lnbio.cnpem.br
dataset submitter
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Dataset FTP location
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