PXD027513

PXD027513 is an original dataset announced via ProteomeXchange.

Title	PUMILIO Proteins in Colorectal Cancer: Tumor Growth Promoting Function and Potential as Therapeutic Targets
Description	We employ Mass spectrum to investigate proteome of Pum1-Knockout, Pum2-Knockout and WT conditions in human colorectal cancer cell line Hct116. Overall design: In order to investigate whether Pum1 and Pum2 regulate their targets at their protein levels, we used Pum1-Knockout, Pum2-Knockout and WT Hct116 cell line to extract total protein for Mass spectrum.
HostingRepository	iProX
AnnounceDate	2021-07-23
AnnouncementXML	Submission_2023-02-02_19:04:59.175.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuanyuan Gong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	TMT6plex reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-22 23:21:32	ID requested
1	2023-01-03 02:03:50	announced
⏵ 2	2023-02-02 19:05:00	announced	2023-02-03: Update publication information.

Gong Y, Liu Z, Yuan Y, Yang Z, Zhang J, Lu Q, Wang W, Fang C, Lin H, Liu S, PUMILIO proteins promote colorectal cancer growth via suppressing p21. Nat Commun, 13(1):1627(2022) [pubmed]

submitter keyword: human colorectal cancer, Pumilio protein, TMT, LC-MS

Haifan Lin
contact affiliation	Shanghai Institute for Advanced Immunochemical Studies
contact email	linhf@shanghaitech.edu.cn
lab head
Yuanyuan Gong
contact affiliation	Shanghai Institute for Advanced Immunochemical Studies
contact email	944942666@qq.com
dataset submitter

iProX dataset URI