PXD027099 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | plasma proteomic profiling reveals Dampness Heat Diarrhea mechanisms in calves |
Description | Dampness heat diarrhea (DHD) is the leading cause in calves with diarrhea in traditional Chinese medicine (TCM). However, the methods for detecting DHD diarrhea remain subjective or infective. To address this issue, the calves with dampness heat diarrhea were collected and the plasma proteomic was analyzed using data-independent acquisition (DIA)-mass spectrometry- based proteomics. The analysis revealed a total of 52 differentially expressed proteins that were uniquely altered in the DHD calves’ plasma, compared to the control. Bioinformatics analysis showed that these altered proteins were involved in a wide range of biological processes, such as intestinal immune network for IgA production, purine metabolism and PI3K signaling pathway, which implying their potential roles in DHD. |
HostingRepository | PRIDE |
AnnounceDate | 2022-10-14 |
AnnouncementXML | Submission_2022-10-14_03:21:59.007.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | ZunxiangYan |
SpeciesList | scientific name: Bos taurus (Bovine); NCBI TaxID: 9913; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-07-05 02:06:57 | ID requested | |
⏵ 1 | 2022-10-14 03:21:59 | announced | |
2 | 2023-11-14 07:29:31 | announced | 2023-11-14: Updated project metadata. |
Publication List
Yan Z, Zhang K, Wang G, Wang L, Zhang J, Qiu Z, Guo Z, Zhang K, Li J, Differential proteomic of plasma provides a new perspective on scientific diagnosis and drug screening for dampness heat diarrhea in calves. Front Vet Sci, 9():986329(2022) [pubmed] |
Keyword List
submitter keyword: dampness heat diarrhea, calves, proteome,data-independent acquisition |
Contact List
JianxiLi |
contact affiliation | Lanzhou institute of husbandry and pharmaceutical sciences of CAASLanzhou institute of husbandry and pharmaceutical sciences of CAAS |
contact email | 492876646@qq.com |
lab head | |
ZunxiangYan |
contact affiliation | Lanzhou institute of husbandry and pharmaceutical sciences of CAAS |
contact email | 743318367@qq.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD027099 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027099
- Label: PRIDE project
- Name: plasma proteomic profiling reveals Dampness Heat Diarrhea mechanisms in calves