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PXD026978-1

PXD026978 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSex-specific social behavior and amygdala proteomic deficits in Foxp2+/- mutant mice
DescriptionIn humans, mutations in the transcription factor encoding gene, FOXP2, are associated with language and Autism Spectrum (ASD) Disorders, the latter characterized by deficits in social interactions. However, little is known regarding the function of Foxp2 in male or female social behavior. Our previous studies in mice revealed high expression of Foxp2 within the medial subnucleus of the amygdala (MeA), a limbic brain region highly implicated in innate social behaviors such as mating, aggression, and parental care. Here, using a comprehensive panel of behavioral tests in male and female Foxp2+/- heterozygous mice, we investigated the role Foxp2 plays in MeA-linked innate social behaviors. We reveal significant deficits in olfactory processing, social interaction, mating, aggressive and parental behaviors. Interestingly, some of these deficits displayed in a sex-specific manner. To examine the consequences of Foxp2 loss of function specifically in the MeA, we conducted a proteomic analysis of microdissected MeA tissue and found sex differences in a host of proteins implicated in neuronal communication, connectivity and dopamine signaling. Consistent with this, we discovered that MeA Foxp2-lineage cells were responsive to dopamine with differences between males and females. Thus, our findings reveal a central and sex-specific role for Foxp2 in social behavior and MeA function.
HostingRepositoryPRIDE
AnnounceDate2021-07-07
AnnouncementXMLSubmission_2021-07-06_23:40:49.634.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMaria Jesus Herrero
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-28 21:20:03ID requested
12021-07-06 23:40:50announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Foxp2, medial amygdala (MeA), social behavior, aggression, sex-specific differences, proteomics
Contact List
Joshua Corbin
contact affiliationCenter for Neuroscience Research, Children's National Hospital, Washington, DC. 20010 USA
contact emailJCorbin@childrensnational.org
lab head
Maria Jesus Herrero
contact affiliationChildren's National Medical Center
contact emailmjhr@um.es
dataset submitter
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Dataset FTP location
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