PXD026904-1

PXD026904 is an original dataset announced via ProteomeXchange.

Title	CAMKK and CRAC channel regulate autophagy, differentiation and apoptosis in acute promylocytic leukemia cells treated by ATRA
Description	ATRA is an active metabolite of vitamin A that is frequently used for the treatment of acute promyelocytic leukemia (APL) patients. Despite the success of this treatment, some APL patients are refractory or relapse. This emphasis the need for new therapeutic strategies aiming to improve the anti-cancer effect of ATRA. We and other have previously shown that autophagy is activated during ATRA-induced granulocytic differentiation of acute promyelocytic leukemia cells. Although the transcription effect of ATRA on autophagy has been well-documented, little is known on the post-transcription/ post-translational regulation autophagy in response to ATRA. Given the importance of calcium ions in the control of autophagy, we hypothesized that calcium ions are involved in the initiation of autophagy by ATRA in APL cells. We thus examined how ATRA regulate intracellular calcium and sense perturbation of Ca2+ responses to autophagy, differentiation and cell death in APL cells.
HostingRepository	PRIDE
AnnounceDate	2021-11-24
AnnouncementXML	Submission_2021-11-24_14:45:29.045.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dupuy Jean-William
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2021-06-24 03:40:56	ID requested
⏵ 1	2021-11-24 14:45:29	announced

Dataset with its publication pending

submitter keyword: Calcium signaling, autophagy, differentiation, cell death , acute promyelocytic leukemai quantitative proteome

Mojgan Djavaheri-Mergny
contact affiliation	a) Centre de Recherche des Cordeliers (CRC), Université de Paris, Sorbonne Université, INSERM, Institut Universitaire de France, Paris, France. b) Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.
contact email	mojgan.mergny@inserm.fr
lab head
Dupuy Jean-William
contact affiliation	Plateforme Proteome Bordeaux
contact email	jean-william.dupuy@u-bordeaux.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD026904
     1. Label: PRIDE project
     2. Name: CAMKK and CRAC channel regulate autophagy, differentiation and apoptosis in acute promylocytic leukemia cells treated by ATRA