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PXD026904 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCAMKK and CRAC channel regulate autophagy, differentiation and apoptosis in acute promylocytic leukemia cells treated by ATRA
DescriptionATRA is an active metabolite of vitamin A that is frequently used for the treatment of acute promyelocytic leukemia (APL) patients. Despite the success of this treatment, some APL patients are refractory or relapse. This emphasis the need for new therapeutic strategies aiming to improve the anti-cancer effect of ATRA. We and other have previously shown that autophagy is activated during ATRA-induced granulocytic differentiation of acute promyelocytic leukemia cells. Although the transcription effect of ATRA on autophagy has been well-documented, little is known on the post-transcription/ post-translational regulation autophagy in response to ATRA. Given the importance of calcium ions in the control of autophagy, we hypothesized that calcium ions are involved in the initiation of autophagy by ATRA in APL cells. We thus examined how ATRA regulate intracellular calcium and sense perturbation of Ca2+ responses to autophagy, differentiation and cell death in APL cells.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDupuy Jean-William
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-24 03:40:56ID requested
12021-11-24 14:45:29announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Calcium signaling, autophagy, differentiation, cell death , acute promyelocytic leukemai quantitative proteome
Contact List
Mojgan Djavaheri-Mergny
contact affiliationa) Centre de Recherche des Cordeliers (CRC), Université de Paris, Sorbonne Université, INSERM, Institut Universitaire de France, Paris, France. b) Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.
contact emailmojgan.mergny@inserm.fr
lab head
Dupuy Jean-William
contact affiliationPlateforme Proteome Bordeaux
contact emailjean-william.dupuy@u-bordeaux.fr
dataset submitter
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Dataset FTP location
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