PXD026409-1
PXD026409 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | MEST Promotes Lung Cancer Invasion and Metastasis by Interacting with VCP to Activate NF-κB Signaling |
Description | Active cell invasion is a hallmark of metastatic cancer, leading to unfavorable clinical outcome. We here established high-invasive lung cancer cell models, A549-i8 and H1299-i8, and identified mesoderm-specific transcript (MEST) as a novel invasive regulator for lung cancer. MEST overexpression promoted the metastasis of lung cancer cells in vivo and in vitro by activating NF-κB signaling. MEST enhanced the interaction of VCP with IκBα, which accelerated IκBα degradation and NF-κB activation. Such an acceleration could be abrogated by VCP silencing, indicating that MEST is an upstream regulator to induce the sequential VCP/IκBα/NF-κB signaling. Furthermore, high MEST and VCP expressions were associated with poor survival of lung cancer patients. Collectively, we demonstrated that MEST plays an important role in driving invasion and metastasis of lung cancer by interacting with VCP, coordinating IκBα/NF-κB pathway. Targeting MEST/VCP/IκBα/NF-κB signaling may represent a promising therapeutic strategy for lung cancer. |
HostingRepository | iProX |
AnnounceDate | 2021-06-02 |
AnnouncementXML | Submission_2022-11-14_23:55:45.507.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jing Zhang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap; Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-06-01 22:06:26 | ID requested | |
⏵ 1 | 2022-11-14 23:55:46 | announced |
Publication List
Wang Y, Zhang J, Li YJ, Yu NN, Liu WT, Liang JZ, Xu WW, Sun ZH, Li B, He QY, B signaling. J Exp Clin Cancer Res, 40(1):301(2021) [pubmed] |
Keyword List
submitter keyword: Lung cancer, MEST, VCP, NF-κB, Metastasis |
Contact List
Yang Wang | |
---|---|
contact affiliation | Jinan University |
contact email | wangyang8857@gmail.com |
lab head | |
Jing Zhang | |
contact affiliation | Jinan University |
contact email | zj6410@jnu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |