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PXD026358-1

PXD026358 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress
DescriptionA 2D-LC-MS/MS strategy coupled with TMT-10 labeling was applied to mouse pancreatic beta cells (hetaTC-6) induced with ER stress by Thapsigargin to study the global proteome and protein cysteine PTM changes under ER stress. Samples were digested with trypsin, labeled with 10-plex TMT, then analyzed by LC-MS/MS. Data was searched with MS-GF+ using PNNL's DMS processing pipeline
HostingRepositoryMassIVE
AnnounceDate2022-08-16
AnnouncementXMLSubmission_2022-08-16_09:11:31.462.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMatthew Monroe
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListTMT6plex; Oxidation; Glutathione; Dioxidation; Trioxidation; Dehydro; Nitrosyl; unknown modification
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-05-29 20:39:16ID requested
12022-08-16 09:11:31announced
Publication List
no publication
Keyword List
submitter keyword: Redox PTMs, pancreatic beta cells, ER stress
Contact List
Wei-Jun Qian
contact affiliationPacific Northwest National Laboratory
contact emailWeijun.Qian@pnnl.gov
lab head
Matthew Monroe
contact affiliationPacific Northwest National Laboratory
contact emailmatthew.monroe@pnnl.gov
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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