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PXD025870-1

PXD025870 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCharacterisation of a nucleo-adhesome
DescriptionIn addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report that nuclear proteomes contain a class of adhesome components that localise to the nucleus. We here defined a nucleo-adhesome, providing experimental evidence for a remarkable scale of nuclear localisation of adhesion proteins, establishing a framework for interrogating nuclear adhesion protein functions.
HostingRepositoryPRIDE
AnnounceDate2022-06-01
AnnouncementXMLSubmission_2022-06-01_03:37:07.245.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAdam Byron
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListcarbamoylated residue; 2-pyrrolidone-5-carboxylic acid (Gln); monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-05-07 04:24:16ID requested
12022-06-01 03:37:07announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: human, nucleus, adhesion, adhesome
Contact List
Margaret Frame
contact affiliationUniversity of Edinburgh
contact emailm.frame@ed.ac.uk
lab head
Adam Byron
contact affiliationUniversity of Edinburgh
contact emailadam.byron@igmm.ed.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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