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PXD025662 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMolecular architecture of the human tRNA ligase complex
DescriptionChemical cross-linking coupled to mass spectrometry was used to study two tRNA ligase complexes, one consisting of subunits RTCB, DDX1, CGI-99, FAM98B and Ashwin (“full tRLC”) and one lacking Ashwin (“core tRLC”). Cross-linking was performed using the homobifunctional, noncleavable reagent, disuccinimidyl suberate (DSS).
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAlexander Leitner
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-04-27 08:33:46ID requested
12021-12-15 02:28:57announced
22021-12-20 11:33:32announced2021-12-20: Updated publication reference for PubMed record(s): 34854379.
Publication List
Kroupova A, Ackle F, Asanović I, Weitzer S, Boneberg FM, Faini M, Leitner A, Chui A, Aebersold R, Martinez J, Jinek M, Molecular architecture of the human tRNA ligase complex. Elife, 10():(2021) [pubmed]
Keyword List
submitter keyword: Chemical cross-linking
structural proteomics
protein complex
tRNA ligase complex
Contact List
Martin Jinek
contact affiliationDepartment of Biochemistry, University of Zurich, Zurich, Switzerland
contact emailjinek@bioc.uzh.ch
lab head
Alexander Leitner
contact affiliationETH Zurich, Institute of Molecular Systems Biology
contact emailleitner@imsb.biol.ethz.ch
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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