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PXD025107-1

PXD025107 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleData on nucleoid-associated proteins isolated from Mycoplasma gallisepticum after intracellular infection
DescriptionMycoplasma gallisepticum belongs to the class Mollicutes. It causes chronic respiratory disease in avian species. M. gallisepticum is characterized by lack of cell wall; reduced genome size and the volume of its nucleoid is comparable to the size of the whole cell. As a result of genome reduction, M. gallisepticum has a limited variety of DNA-binding proteins (DBP) and transcription factors. It was shown, however, that mycoplasmas demonstrate a wide range of differential expression in response to various stress factors, which promotes effective adaptation to unfavorable conditions. We assume that in the case of mycoplasmas, which are characterized by a combination of the reduction of known gene expression regulation systems and a high adaptive potential, the coordination of gene expression can be provided due to local changes in the structure and spatial organization of the chromosome. The study of the dynamic changes of the proteomic profile of M. gallisepticum nucleoid may assist in revealing its mechanisms of functioning, regulation of chromosome organization and stress adaptation including its changes upon invasion of the host cells.
HostingRepositoryPRIDE
AnnounceDate2021-03-31
AnnouncementXMLSubmission_2021-03-31_03:13:41.114.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAleksandr Zubov
SpeciesList scientific name: Mycoplasma gallisepticum S6; NCBI TaxID: 1006581;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-30 10:41:39ID requested
12021-03-31 03:13:41announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: mycoplasma gallisepticum, intracellular infection, LC-MS/MS, shotgun proteomics, nucleoid-associated peoteins
Contact List
Gleb Fisunov
contact affiliationLab of Proteome Research, Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia
contact emailherr.romanoff@gmail.com
lab head
Aleksandr Zubov
contact affiliationLab of Proteome Research, Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow
contact emailalexanderzubov@icloud.com
dataset submitter
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Dataset FTP location
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