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PXD025066-1

PXD025066 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFuran warheads for covalent trapping of weak protein-protein interactions: specific cross-linking of thymosin β4 to actin
DescriptionWe describe furan as a triggerable ‘warhead’ for site-specific cross-linking using the actin and thymosin β4 (Tβ4)-complex as model of a weak and dynamic protein-protein interaction with known 3D structure and with application potential in disease contexts. The presented in vitro validation of covalently acting ‘furan-armed’ Tβ4-variants provides initial proof to further exploit furan-technology for covalent drug design.
HostingRepositoryPRIDE
AnnounceDate2021-05-13
AnnouncementXMLSubmission_2021-05-13_05:03:08.435.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD025066
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMarina Gay
SpeciesList scientific name: Oryctolagus sp. 'Rabbit_OD'; NCBI TaxID: 2665958;
ModificationListmonohydroxylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-29 06:48:22ID requested
12021-05-13 05:03:08announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Furan, protein-protein interactions, covalent, cross-link, cross-linked peptide, actin, Thymosin β4, mass spectrometry
Contact List
Annemieke Madder
contact affiliationOrganic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Faculty of Science, Ghent University, Krijgslaan 281 S4, B-9000 Ghent, Belgium
contact emailAnnemieke.Madder@Ugent.be
lab head
Marina Gay
contact affiliationInstitute for Research in Biomedicine
contact emailmarina.gay@irbbarcelona.org
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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