PXD024940 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | LAMTOR1 interactome upon knock out of USP32 |
Description | Ubiquitination is among the most prevalent post-translational modifications regulating a great number of cellular functions, and defects in such processes contribute to many diseases. Deubiquitinating enzymes (DUBs) are essential to control the precise outcome of ubiquitin signals. The ubiquitin-specific protease 32 (USP32) differs from all other DUBs as it comprises in addition to its catalytic USP domain and the DUSP domain also multiple EF hands and a C-terminal prenylation site. This dataset represents an interactome analysis of GFP-tagged LAMTOR1 in human RPE-1 cells upon knock-out of USP32. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:34:58.419.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Georg Tascher |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | ubiquitination signature dipeptidyl lysine |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-23 03:38:27 | ID requested | |
1 | 2023-01-16 03:58:49 | announced | |
⏵ 2 | 2023-11-14 08:34:59 | announced | 2023-11-14: Updated project metadata. |
Publication List
Hertel A, Alves LM, Dutz H, Tascher G, Bonn F, Kaulich M, Dikic I, Eimer S, Steinberg F, Bremm A, USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Cell Rep, 41(10):111653(2022) [pubmed] |
Keyword List
submitter keyword: Q Exactive HF, LFQ,LAMTOR1, ubiquitin, USP32, LC-MS/MS |
Contact List
Anja Bremm |
contact affiliation | Institute of Biochemistry II, Faculty of Medicine, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany |
contact email | bremm@em.uni-frankfurt.de |
lab head | |
Georg Tascher |
contact affiliation | Institute of Biochemistry II, Goethe University Hospital Frankfurt/Main, Germany |
contact email | tascher@med.uni-frankfurt.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD024940 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024940
- Label: PRIDE project
- Name: LAMTOR1 interactome upon knock out of USP32