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PXD024625-1

PXD024625 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder
DescriptionWe identified that peroxins were still expressed in Zellweger Spectrum Disorder (ZSD) and a subset of them accumulated on the mitochondrial membrane, which resulted in gross mitochondrial abnormalities and impaired mitochondrial metabolic function. In this complexome analysis we detected several peroxins in the mitochondrial fraction in the absence of functional peroxisomes and that this accumulation is exacerbated by the loss of the mitochondrial extractase Msp1. In addition, we observed that specific peroxisomal matrix proteins localize to the mitochondria, which suggest that a functional peroxisomal docking and import complex assembles on the mitochondria in the absence of peroxisomes.
HostingRepositoryPRIDE
AnnounceDate2021-06-25
AnnouncementXMLSubmission_2021-06-25_00:42:14.844.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterIlka Wittig
SpeciesList scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-10 00:05:37ID requested
12021-06-25 00:42:15announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: LC-MSMS, complexome profiling, mitochondria, peroxisomes, peroxisomal biogenesis disorder, peroxisomal import, mitocondrial quality control
Contact List
Jared Rutter
contact affiliationMedical School, Department of Biochemistry, University of Utah, Salt Lake City, USA
contact emailrutter@biochem.utah.edu
lab head
Ilka Wittig
contact affiliationFunctional Proteomics, Goethe University, Frankfurt am Main , Germany
contact emailwittig@med.uni-frankfurt.de
dataset submitter
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Dataset FTP location
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