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PXD024531-1

PXD024531 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAlternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability
Descriptionwe generated nuclear and cytoplasmic extracts from FLAG-LARP4 cells, purified LARP4, using FLAG affinity resin, and analyzed the purified complexes, using mass spectrometry. Consistent with previous reports, LARP4 is primarily, but not exclusively, cytoplasmic, and we could robustly detect associated proteins involved in poly(A)-binding. Surprisingly, we also detected numerous components of the cleavage and polyadenylation machinery associated with LARP4, suggesting a potential direct role in APA regulation
HostingRepositoryMassIVE
AnnounceDate2021-03-08
AnnouncementXMLSubmission_2021-03-08_12:39:43.983.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterBill Russell
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion ETD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-04 15:59:19ID requested
12021-03-08 12:39:44announced
Publication List
no publication
Keyword List
submitter keyword: Poly(A), APMS, LCMS
Contact List
William Russell
contact affiliationUTMB
contact emailbill.russell@utmb.edu
lab head
Bill Russell
contact affiliationUTMB
contact emailbill.russell@utmb.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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