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PXD024356-1

PXD024356 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleOrgan-specific inflammaging in mice
DescriptionAging is accompanied by chronic, low-grade systemic inflammation, termed inflammaging, a main driver of age-associated diseases. Such sterile inflammation is typically characterized by elevated levels of pro-inflammatory mediators, such as cytokines and reactive oxygen species causing organ damage. Lipid mediators play important roles in the fine-tuning of both the promotion and the resolution of inflammation. Yet, it remains unclear how lipid mediators fit within the concept of inflammaging and how their biosynthesis and function is affected by aging. Here, we provide comprehensive signature profiles of inflammatory markers in organs afflicted with inflammation of young and old C57BL/6 mice. We reveal an organ-specific footprint of inflammation-related cytokines, chemokines and lipid mediators, which are distinctively affected by aging. While some organs are characterized by a pronounced pro-inflammatory microenvironment and impaired resolution during aging, others display elevated levels of pro-resolving mediators or an overall decrease in inflammatory signaling. Our results demonstrate that it proves difficult to establish a unifying concept for alterations of immunomodulatory mediators as consequence of aging and that organ specificity needs to be considered. Moreover, our data imply that inclusion of lipid mediators into the concept of inflammaging provides a comprehensive tool to characterize the inflammatory microenvironment during aging on a broader and yet, more detailed scope.
HostingRepositoryPRIDE
AnnounceDate2021-03-22
AnnouncementXMLSubmission_2021-03-22_02:02:59.820.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterEmilio Cirri
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-02-24 04:55:36ID requested
12021-03-22 02:03:00announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: aging, inflammation, resolution, cytokines, lipid mediators, proteomics
Contact List
Oliver Werz
contact affiliationDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743 Jena, Germany
contact emailoliver.werz@uni-jena.de
lab head
Emilio Cirri
contact affiliationLeibniz Institute on Ageing Fritz Lipmann Institute Jena
contact emailemilio.cirri@fli-leibniz.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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