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PXD024294-1

PXD024294 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlemiR-146 modulation in ALS astrocytes
DescriptionRegarding astrocytes and microglia, we are looking for pathways related with inflammatory activation, phagocytosis and vesicular/exosome trafficking. Regarding motor neurons, we are searching for pathways related with mitochondrial dynamics, Endoplasmic Reticulum stress, cell death, axonal transport, synaptic vesicles transport and oxidative stress. The general aim is to identify putative hits in ALS that relates with miR-146a expression.
HostingRepositoryPRIDE
AnnounceDate2021-04-06
AnnouncementXMLSubmission_2021-04-06_00:20:19.640.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFrank Stein
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-02-22 01:45:10ID requested
12021-04-06 00:20:20announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: ALS
miR-146a
astrcoyte
motor neuron
microglia
Contact List
Dora Brites
contact affiliationNeuron Glia Biology in Health and Disease Group, iMed.Ulisboa, Faculty of pharmacy, University of Lisbon, Lisbon, Portugal
contact emailarmvaz@ff.ulisboa.pt
lab head
Frank Stein
contact affiliationEMBL
contact emailfrank.stein@embl.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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