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PXD024172-1

PXD024172 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies
DescriptionHIV-1 latency is a major obstacle to achieve a functional cure for AIDS. To eradicate the viral reservoir, one of the strategies is to specifically reactivate HIV-1-infected cells and followed by elimination with potent immune surveillance. However, present latency-reversing agents (LRAs) are quite dissatisfactory because of their high toxicity and low efficiency. New targets need to be identified to develop more promising LRAs. Here, we found that histone chaperone chromatin assembly factor 1 (CAF-1) promotes HIV-1 latency by forming versatile suppressive nuclear bodies. CAF-1 plays a leading role for the formation of bodies recruiting multi-layer suppressive epigenetic modifiers and maintainers, and is of the characteristic of liquid-liquid phase separation (LLPS). Three distinct disordered regions of CHAF1A subunit coalesce CAF-1 body components by forming LLPS and play a key in maintaining HIV-1 latency. Therefore, disruptive induction of phase-separated CAF-1 body could be an important strategy to reactivate latent HIV-1.
HostingRepositoryiProX
AnnounceDate2021-02-09
AnnouncementXMLSubmission_2021-02-15_00:58:34.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXiancai Ma
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-02-15 00:58:05ID requested
12021-02-15 00:58:34announced
22021-04-22 17:22:54announced2021-04-23: Update publication information.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: CAF-1
Contact List
Hui Zhang
contact affiliationSun Yat-sen University
contact emailzhangh92@mail.sysu.edu.cn
lab head
Xiancai Ma
contact affiliationSun Yat-sen University
contact emailmaxc@mail2.sysu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI