PXD024152 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mesenchymal treatment of the salivary glands upregulates proteins with regenerative potential in irradiated patients |
Description | Damage to the major salivary glands is the leading long-term side effect to radiation therapy in patients with head and neck cancerof radiation of head and neck cancers,. It resultresultsing in severe hyposalivationdry mouth , which profoundly impairs basic physiological functions for patients such as speaking, eating, tasting, and swallowing. TodayCurrently, no effective treatment can be offeredexists to alleviate radiation-induced hyposalivation, but recently, treatment with adipose tissue-derived mesenchymal stem/stromal cells (ASC) hasve very recently been tested as a newshowed potential treatment modalityfor restoring the function of the salivary glands. However, the impact of ASC-treatments on the salivary gland proteinome composition has notever been testedinvestigated. HereIn this study, we examine the salivary gland proteomeuse in patients with severe hyposalivation due to radiation therapy and in healthy controls using quantitative metaproteomics. Furthermore, to 1: compare the salivary proteome in patients with severe hyposalivation to that of healthy controls, and 2: towe addresslongitudinally monitorinvestigate the effect of ASC ASC-treatment on the salivary gland proteome. We identify that treatment with ASC-treatments results inis associated with the upregulation of specific proteins in saliva 120 days after injection. Therefore, oOur data findings suggest that ASCs to stimulate biological processes in the salivary gland tissue, which could have beneficial clinical effects. |
HostingRepository | PRIDE |
AnnounceDate | 2022-11-24 |
AnnouncementXML | Submission_2022-11-24_00:59:58.969.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | RosaJersie-Christensen |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-02-11 23:15:23 | ID requested | |
⏵ 1 | 2022-11-24 00:59:59 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Radiotherapy ,Stem cell therapy , Cancer, Salivary glands, saliva, Proteomics, Regenerative medicine |
Contact List
Rosa R.Jersie-Christensen |
contact affiliation | Department of Science and Environment, Roskilde University, Roskilde, Denmark |
contact email | rrj@ruc.dk |
lab head | |
RosaJersie-Christensen |
contact affiliation | Roskilde University |
contact email | rrj@ruc.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD024152 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024152
- Label: PRIDE project
- Name: Mesenchymal treatment of the salivary glands upregulates proteins with regenerative potential in irradiated patients