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PXD024152 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMesenchymal treatment of the salivary glands upregulates proteins with regenerative potential in irradiated patients
DescriptionDamage to the major salivary glands is the leading long-term side effect to radiation therapy in patients with head and neck cancerof radiation of head and neck cancers,. It resultresultsing in severe hyposalivationdry mouth , which profoundly impairs basic physiological functions for patients such as speaking, eating, tasting, and swallowing. TodayCurrently, no effective treatment can be offeredexists to alleviate radiation-induced hyposalivation, but recently, treatment with adipose tissue-derived mesenchymal stem/stromal cells (ASC) hasve very recently been tested as a newshowed potential treatment modalityfor restoring the function of the salivary glands. However, the impact of ASC-treatments on the salivary gland proteinome composition has notever been testedinvestigated. HereIn this study, we examine the salivary gland proteomeuse in patients with severe hyposalivation due to radiation therapy and in healthy controls using quantitative metaproteomics. Furthermore, to 1: compare the salivary proteome in patients with severe hyposalivation to that of healthy controls, and 2: towe addresslongitudinally monitorinvestigate the effect of ASC ASC-treatment on the salivary gland proteome. We identify that treatment with ASC-treatments results inis associated with the upregulation of specific proteins in saliva 120 days after injection. Therefore, oOur data findings suggest that ASCs to stimulate biological processes in the salivary gland tissue, which could have beneficial clinical effects.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-02-11 23:15:23ID requested
12022-11-24 00:59:59announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Radiotherapy ,Stem cell therapy , Cancer, Salivary glands, saliva, Proteomics, Regenerative medicine
Contact List
Rosa R.Jersie-Christensen
contact affiliationDepartment of Science and Environment, Roskilde University, Roskilde, Denmark
contact emailrrj@ruc.dk
lab head
contact affiliationRoskilde University
contact emailrrj@ruc.dk
dataset submitter
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Dataset FTP location
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