PXD023829 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Multilayered Omics Revealsl Sex- and Depot-Dependent Adipose Progenitor Cell Heterogeneity |
Description | White adipose tissue (WAT) harbors functionally diverse subpopulations of adipose progenitor cells that differentially impact tissue plasticity in a sex- and depot-dependent manner. To date, the molecular basis of this cellular heterogeneity has not been fully defined. Here, we describe a multilayered omics approach to dissect adipose progenitor cell heterogeneity from in three dimensions: progenitor subpopulation, sex, and anatomical localization. We applied state-of-the-art mass spectrometry methods to quantify 4870 proteins in eight different stromal cell populations from perigonadal and inguinal WAT of male and female mice and acquired transcript expression levels of 15477 genes using RNA-seq. Notably, our data highlight the molecular signatures defining sex differences in PDGFR+ preadipocyte differentiation and identify regulatory pathways that functionally distinguish adipose tissue PDGFRb+ subpopulations. The data are freely accessible as a resource at "Pread Profiler. Together, the multilayered omics analysis provides unprecedented insights into adipose stromal cell heterogeneity. |
HostingRepository | PRIDE |
AnnounceDate | 2023-03-11 |
AnnouncementXML | Submission_2023-03-10_21:23:10.076.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | MidyWu |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-01-26 02:19:24 | ID requested | |
⏵ 1 | 2023-03-10 21:23:10 | announced | |
2 | 2023-11-14 08:37:23 | announced | 2023-11-14: Updated project metadata. |
Publication List
Shan B, Barker CS, Shao M, Zhang Q, Gupta RK, Wu Y, Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity. Cell Metab, 34(5):783-799.e7(2022) [pubmed] |
Keyword List
submitter keyword: Multilayered omics, adipogenesis, inflammation, preadipocytes, PPAR., adipocyte precursor cells, cellular heterogeneity |
Contact List
YiboWu |
contact affiliation | RIKEN Center for Integrative Medical Sciences |
contact email | yibo.wu@riken.jp |
lab head | |
MidyWu |
contact affiliation | RIKEN |
contact email | wyb0828@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023829
- Label: PRIDE project
- Name: Multilayered Omics Revealsl Sex- and Depot-Dependent Adipose Progenitor Cell Heterogeneity