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PXD023562-1

PXD023562 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBroad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy
DescriptionTauopathies are a group of more than twenty known disorders that involve progressive neurodegeneration, cognitive decline, and pathological tau accumulation. Current therapeutic strategies provide only limited, late-stage symptomatic treatment. This is partly due to lack of understanding of the molecular mechanisms linking tau and cellular dysfunction, especially during the early stages of disease progression. In this study, we treated tau transgenic mice with a multi-target kinase inhibitor to identify novel targets that contribute to cognitive impairment and exhibit therapeutic potential. Drug treatment significantly ameliorated brain atrophy and neuronal function as determined by behavioral testing and a sensitive imaging technique called manganese-enhanced magnetic resonance imaging (MEMRI) with quantitative R1 mapping. Surprisingly, these benefits occurred despite unchanged hyperphosphorylated tau levels. To elucidate the mechanism behind these improved cognitive outcomes, we performed quantitative proteomics to determine the altered protein network during this early stage in tauopathy and compare this model with the human AD proteome. We identified a cluster of preserved pathways shared with human tauopathy with striking potential for broad multi-target kinase intervention. We further report high confidence
HostingRepositoryPRIDE
AnnounceDate2021-02-02
AnnouncementXMLSubmission_2021-02-01_23:43:30.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDuc Duong
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-01-13 00:15:41ID requested
12021-02-01 23:43:30announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Mouse LC-MS/MS
Contact List
Jose F. Abisambra
contact affiliation1Department of Neuroscience & Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA
contact emailj.abisambra@ufl.edu
lab head
Duc Duong
contact affiliationCenter of Neurodegenerative Diseases
contact emaildduong@emory.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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