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PXD023437-1

PXD023437 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNeuronal Nsun2 deficiency is associated with codon-specific epitranscriptomic dysregulation of Gly-tRNAs and corresponding proteomic shift impacting synaptic signaling and behavior
DescriptionThe role of transfer (t)RNA cytosine methyl-transferases as epitranscriptomic regulators of brain proteomes remains unexplored. We report that fear memory and antidepressant-like behaviors are highly sensitive to bi-directional changes in Nsun2 tRNA methyltransferase activity in prefrontal cortex (PFC) neurons. Nsun2-deficient mutant cortex showed a selective deficit in multiple glycine tRNAs, resulting in codon-specific shifts in translational efficiencies and a distorted proteomic landscape with deficits in glycine-rich neuronal proteins impacting synaptic signaling and behavior.
HostingRepositoryPRIDE
AnnounceDate2021-07-02
AnnouncementXMLSubmission_2021-07-01_23:11:34.173.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSoren Heissel
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-01-06 03:29:05ID requested
12021-07-01 23:11:34announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: TMT, NSUN2, Neurons
Contact List
Schahram Akbarian
contact affiliationDepartments of Neuroscience and Psychiatry, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
contact emailschahram.akbarian@mssm.edu
lab head
Soren Heissel
contact affiliationResearch Support Specialist
contact emailsheissel@rockefeller.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
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