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PXD023228-1

PXD023228 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of the secretome of seven Leishmania species
DescriptionThis study provides a comprehensive analysis of the secretome of seven different Leishmania species (six main human pathogenic species: L. donovani, L. infantum, L. braziliensis, L. major, L. amazonensis, L. tropica) and L. tarentolae, non-pathogenic to humans, produced by promastigotes cultured in serum-free conditions. The exhaustive analysis of the protein content of the secretome using mass spectrometry led to the identification of common and unique proteins, as well as useful insights on the relation between secretome content and pathogenesis. The biological relevance of the secretome is undeniable and, in the particular case of Leishmania parasites, it is a crucial player in the host-pathogen interactions which dictate the outcome of infection and disease severity. This study actively contributes to current knowledge on Leishmania biology and the generated datasets are an addition to current databases, associating the identified proteins with subcellular localization and putative extracellular functions.
HostingRepositoryPRIDE
AnnounceDate2021-11-29
AnnouncementXMLSubmission_2021-11-29_06:19:32.535.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFunctional Proteomics Platform FPP
SpeciesList scientific name: Leishmania ; NCBI TaxID: 5658;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap XL
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-12-18 07:05:55ID requested
12021-11-29 06:19:32announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Leishmaniasis, promastigote,Leishmania, secretome
Contact List
Jean-Loup Lemesre
contact affiliationUMR177 INTERTRYP, IRD, Montpellier, France
contact emailjean-loup.lemesre@ird.fr
lab head
Functional Proteomics Platform FPP
contact affiliationFPP CNRS
contact emailcontact@fpp.cnrs.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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