PXD023123 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phosphoproteomics of human MV4-11 AML cells treated with Gilteritinib |
Description | Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in 25% of acute myeloid leukemia (AML) patients and lead to constitutive activation of FLT3, driving leukemia cell survival and proliferation. Quizartinib, crenolanib and gilteritinib are second-generation FLT3 inhibitors (FLT3i) in phase III trials or clinical use for the targeted treatment of FLT3-ITD+ AML. However, they demonstrated only limited benefit and were not curative. A full understanding of cellular resistance factors contributing to this poor response is lacking. Here, we examined cell-autonomous pathways modulated by FLT3i using global translatome and phosphoproteome proteomics to identify non-genetic resistance mechanisms. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-25 |
AnnouncementXML | Submission_2022-08-25_07:06:33.894.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sebastian Koschade |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; alkylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-12-14 06:44:45 | ID requested | |
⏵ 1 | 2022-08-25 07:06:34 | announced | |
Publication List
Koschade SE, Klann K, Shaid S, Vick B, Stratmann JA, Th, ö, lken M, Meyer LM, Nguyen TD, Campe J, Moser LM, Hock S, Baker F, Meyer CT, Wempe F, Serve H, Ullrich E, Jeremias I, M, ü, nch C, Brandts CH, Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia. Leukemia, 36(10):2396-2407(2022) [pubmed] |
Keyword List
submitter keyword: Human, AML, FLT3, LC-MSMS |
Contact List
Christian Münch |
contact affiliation | Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany |
contact email | ch.muench@em.uni-frankfurt.de |
lab head | |
Sebastian Koschade |
contact affiliation | Department of Medicine, Hematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany & Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany |
contact email | koschade@med.uni-frankfurt.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD023123
- Label: PRIDE project
- Name: Phosphoproteomics of human MV4-11 AML cells treated with Gilteritinib