<<< Full experiment listing

PXD023027

PXD023027 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComparison of cerebrospinal fluid proteomics between Demyelinating disease and non-inflammatory neurological controls
DescriptionDemyelinating disease is a disease of the nervous system in which the nerve demyelinating is the main or primary lesion, and the axon, cell body and glia are relatively lightly damaged. It can occur in the central nervous system or the peripheral nervous system. The demyelinating diseases of central nervous system are represented by multiple sclerosis (MS) and neuromyelitis optica (NMO) while Guillain-Barre Syndrome (GBS) is a demyelinating disease of the peripheral nervous system. We aimed to identify the key proteins in demyelinating disease and describe the proteomic pattern of MS, GBS and NMO. This study used high-resolution liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), in combination with quantitative 10-plex tandem mass tag labeling, to profile protein changes in MS, GBS and NMO.
HostingRepositoryiProX
AnnounceDate2020-12-09
AnnouncementXMLSubmission_2023-02-21_18:33:12.958.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRuimin Ma
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-12-09 18:21:16ID requested
12021-08-17 21:36:50announced
22021-08-18 01:24:47announced2021-08-18: Update information.
32023-02-21 18:33:13announced2021-08-18: Update information.
2023-02-22: Update publication information.
Publication List
Shi Y, Ding Y, Li G, Wang L, Osman RA, Sun J, Qian L, Zheng G, Zhang G, Discovery of Novel Biomarkers for Diagnosing and Predicting the Progression of Multiple Sclerosis Using TMT-Based Quantitative Proteomics. Front Immunol, 12():700031(2021) [pubmed]
Keyword List
submitter keyword: Guillain-Barré Syndrome,serum, cerebrospinal fluid, proteomics, calcium imbalance
Contact List
Guojun Zhang
contact affiliationBeijing Tiantan Hospital, Capital medical university
contact emailtiantandr@yeah.net
lab head
Ruimin Ma
contact affiliationBeijing Tiantan Hospital, Capital medical university
contact emailmrmttyy@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI