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PXD022755-1

PXD022755 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56
DescriptionMeiosis creates genetic diversity by recombination and segregation of chromosomes. The synaptonemal complex assembles during meiotic prophase I and assists faithful exchanges between homologous chromosomes, but how its assembly/disassembly is regulated remains to be understood. Here we report how two major post-translational modifications, phosphorylation and ubiquitination, co-operate to promote synaptonemal complex assembly. We found that the ubiquitin ligase complex SCF is important for assembly and maintenance of the synaptonemal complex in Drosophila female meiosis. This function of SCF is mediated by two substrate-recognising F-box proteins, Slmb/βTrcp and Fbxo42. SCF-Fbxo42 downregulates the phosphatase subunit PP2A-B56, which is important for synaptonemal complex assembly and maintenance.
HostingRepositoryPRIDE
AnnounceDate2020-12-07
AnnouncementXMLSubmission_2020-12-07_02:27:08.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterVan Kelly
SpeciesList scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-26 00:21:52ID requested
12020-12-07 02:27:08announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Drosophila
Contact List
Tony Ly
contact affiliationWellcome Centre for Cell Biology, University of Edinburgh
contact emailtony.ly@ed.ac.uk
lab head
Van Kelly
contact affiliationUniversity of Edinburgh
contact emailvan.kelly@ed.ac.uk
dataset submitter
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Dataset FTP location
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PRIDE project URI
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