PXD022523-1

PXD022523 is an original dataset announced via ProteomeXchange.

Title	Delayed induction of type I and III interferons enhances nasal epithelial permissiveness to SARS-CoV-2
Description	We provide the first comprehensive analysis of nasal cell responses to SARS-COV-2 using single cell transcriptomics and proteomics. The immune response to SARS-CoV-2 is dominated by a delayed type I and III IFN response, which is too slow to contain viral replication. Cells transitioning from secretory to ciliated states are highly permissive to SARS-CoV-2, whereas goblet cells are relatively resistant. Cell-type differences in the production and response to IFN-I/III correlate with permissiveness. Pre-treatment with recombinant IFNs potently restricts SARS-CoV-2. Nasal delivery of recombinant IFNs is a promising prophylactic strategy for SARS-CoV-2
HostingRepository	PRIDE
AnnounceDate	2021-05-25
AnnouncementXML	Submission_2021-05-25_08:02:58.839.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matthias Trost
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-13 07:10:52	ID requested
⏵ 1	2021-05-25 08:02:59	announced
2	2023-04-11 06:26:57	announced	2023-04-11: Updated project metadata.

Dataset with its publication pending

ProteomeXchange project tag: Covid-19

submitter keyword: SARS-CoV-2, human, nasal

Matthias Trost
contact affiliation	Newcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK
contact email	matthias.trost@ncl.ac.uk
lab head
Matthias Trost
contact affiliation	Newcastle University
contact email	matthias.trost@ncl.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD022523
     1. Label: PRIDE project
     2. Name: Delayed induction of type I and III interferons enhances nasal epithelial permissiveness to SARS-CoV-2