PXD022238

PXD022238 is an original dataset announced via ProteomeXchange.

Title	Time-series proteome profiling analysis of the atria in a murine model of angiotensin II-induced atrial fibrillation
Description	Atrial fibrillation (AF) is the most common form of arrhythmia observed in clinical cardiac diseases. Angiotensin II (Ang II) and elevation of blood pressure have been considered to be the main risk regulators of AF. However, the time series proteome profiling and the key signaling pathways involved in the development of Ang II-induced AF remain unclear. Wild-type C57BL/6 male mice (10 weeks old) were infused with Ang II (2000 ng/kg/min) for 1, 2 and 3 weeks, respectively. AF inducibility, left atrial volume and fibrosis were examined by echocardiography and histological staining. The time series proteome in atria tissues was evaluated with Isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) technologies. This study defined the dynamic changes of the differentially expressed proteins (DEPs) involved in Ang II-induced AF, and identified that mitochondrial oxidative phosphorylation may play a key role in this disease. These findings provide a resource for understanding the molecular mechanism research of AF.
HostingRepository	PRIDE
AnnounceDate	2022-05-25
AnnouncementXML	Submission_2022-05-25_05:09:46.750.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yun-Long Zhang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-29 02:40:13	ID requested
⏵ 1	2022-05-25 05:09:47	announced

Teng F, Han X, Yu P, Li PB, Li HH, Zhang YL, Time series proteome profile analysis reveals a protective role of citrate synthase in angiotensin II-induced atrial fibrillation. J Hypertens, 40(4):765-775(2022) [pubmed]

submitter keyword: Proteomics

Time series protein expression profiling

Angiotensin II

Atrial fibrillation

Hui Hua Li
contact affiliation	Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, China
contact email	hhli1935@aliyun.com
lab head
Yun-Long Zhang
contact affiliation	Beijing Chaoyang Hospital, Capital Medical University
contact email	zyldy111@vip.163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD022238

PRIDE project URI

• PRIDE
  1. PXD022238
     1. Label: PRIDE project
     2. Name: Time-series proteome profiling analysis of the atria in a murine model of angiotensin II-induced atrial fibrillation