PXD022159-2

PXD022159 is an original dataset announced via ProteomeXchange.

Title	‘The long tail of Covid 19’ - The detection of a prolonged inflammatory response after a SARS-CoV-2 infection in asymptomatic and mildly affected patients
Description	‘Long Covid’ or medical complications associated with a post SARS Covid 2 infection, are a significant post-viral complication that is being more and more commonly reported in patients. Therefore, there is an increasing need to understand the disease mechanisms, identify drug targets and inflammatory processes associated with a Sars-CoV-2 infection. To address this need, we created a targeted mass spectrometry based multiplexed panel of 96 immune response associated proteins. We applied the multiplex assay to a cohort of serum samples from asymptomatic and moderately affected patients. All patients had tested positive for a Sars-CoV-2 infection by PCR and were determined to be subsequently positive for antibodies. Even 40-60 days post-viral infection, we observed a significant remaining inflammatory response in all patients. Proteins that were still affected were associated with the anti-inflammatory response and mitochondrial stress. This indicates that biochemical and inflammatory pathways within the body can remain perturbed long after SARS-CoV2 infections have subsided even in asymptomatic and moderately affected patients.
HostingRepository	PanoramaPublic
AnnounceDate	2021-01-21
AnnouncementXML	Submission_2021-01-21_10:48:14.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Wendy Heywood
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl
Instrument	Xevo TQ-S

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-24 11:30:52	ID requested
1	2020-11-11 09:10:46	announced
⏵ 2	2021-01-21 10:48:15	announced	: Added publication link and PubMed ID

Doykov I, H, ä, llqvist J, Gilmour KC, Grandjean L, Mills K, Heywood WE, 'The long tail of Covid-19' - The detection of a prolonged inflammatory response after a SARS-CoV-2 infection in asymptomatic and mildly affected patients. F1000Res, 9():1349(2020) [pubmed]

submitter keyword: sars-cov-2, covid19, inflammation

Wendy Heywood
contact affiliation	University College London
contact email	wendy.heywood@ucl.ac.uk
lab head
Wendy Heywood
contact affiliation	University College London
contact email	wendy.heywood@ucl.ac.uk
dataset submitter

Panorama Public dataset URI