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PXD022159

PXD022159 is an original dataset announced via ProteomeXchange.

Dataset Summary
Title‘The long tail of Covid 19’ - The detection of a prolonged inflammatory response after a SARS-CoV-2 infection in asymptomatic and mildly affected patients
Description‘Long Covid’ or medical complications associated with a post SARS Covid 2 infection, are a significant post-viral complication that is being more and more commonly reported in patients. Therefore, there is an increasing need to understand the disease mechanisms, identify drug targets and inflammatory processes associated with a Sars-CoV-2 infection. To address this need, we created a targeted mass spectrometry based multiplexed panel of 96 immune response associated proteins. We applied the multiplex assay to a cohort of serum samples from asymptomatic and moderately affected patients. All patients had tested positive for a Sars-CoV-2 infection by PCR and were determined to be subsequently positive for antibodies. Even 40-60 days post-viral infection, we observed a significant remaining inflammatory response in all patients. Proteins that were still affected were associated with the anti-inflammatory response and mitochondrial stress. This indicates that biochemical and inflammatory pathways within the body can remain perturbed long after SARS-CoV2 infections have subsided even in asymptomatic and moderately affected patients.
HostingRepositoryPanoramaPublic
AnnounceDate2020-11-11
AnnouncementXMLSubmission_2020-11-11_09:10:46.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterWendy Heywood
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListCarbamidomethyl
InstrumentXevo TQ-S
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-24 11:30:52ID requested
12020-11-11 09:10:46announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: sars-cov-2, covid19, inflammation
Contact List
Wendy Heywood
contact affiliationUniversity College London
contact emailwendy.heywood@ucl.ac.uk
lab head
Wendy Heywood
contact affiliationUniversity College London
contact emailwendy.heywood@ucl.ac.uk
dataset submitter
Full Dataset Link List
Panorama Public dataset URI