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PXD021646-1

PXD021646 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes
DescriptionSTRIPAK is a highly conserved eukaryotic signalling complex controlling a wide range of developmental processes in microorganisms as well as humans. This study uses iTRAQ-based proteomic and phosphoproteomic analyses to expand the identification of differentially phosphorylated proteins, comparing the wildtype proteome of the model fungus S. macorspora to those from three STRIPAK single- and double deletion mutants. Among the differentially phosphorylated proteins, we detected Gul1, a homolog of GUL-1 from N. crassa and SSD1 from yeast. In this study, we further provide a functional analysis of Gul1, showing it controls sexual development and hyphal morphology in a phosphorylation dependent manner.
HostingRepositoryPRIDE
AnnounceDate2020-09-24
AnnouncementXMLSubmission_2020-09-24_01:50:32.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBernhard Blank-Landeshammer
SpeciesList scientific name: Sordaria macrospora k-hell; NCBI TaxID: 771870;
ModificationListphosphorylated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-09-23 06:56:51ID requested
12020-09-24 01:50:32announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Sordaria macrospora, LC-MSMS, Phosphoproteomics, iTRAQ
Contact List
Prof. Dr. Albert Sickmann
contact affiliationLeibniz-Institut für Analytische Wissenschaften – ISAS – e.V.
contact emailsickmann@isas.de
lab head
Bernhard Blank-Landeshammer
contact affiliationLeibniz-Institut für Analytische Wissenschaften - ISAS e.V.
contact emailblank.bernhard@gmail.com
dataset submitter
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Dataset FTP location
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