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PXD020539-1

PXD020539 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleContribution of the Unfolded Protein Response (UPR) transcription factor XBP1 to brain aging
DescriptionIn this project we aimed to evaluate the contribution of endoplasmic reticulum stress sensor IRE1 and its downstream transcription factor XBP1s to mammalian brain aging. We compared traits associated to aging at behavioral, electrophysiological, morphological and proteomic levels. We used transgenic animals overexpressing XBP1s in brain tissue and also wild type animals injected with adeno-associated virus to overexpress XBP1s in the brain during aging.
HostingRepositoryPRIDE
AnnounceDate2022-11-04
AnnouncementXMLSubmission_2022-11-04_05:19:58.095.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLarsPlate
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-07-23 17:45:48ID requested
12022-11-04 05:19:58announced
22023-11-14 08:51:22announced2023-11-14: Updated project metadata.
Publication List
Keyword List
submitter keyword: unfolded protein response, XBP1s, dementia, aging
Contact List
LarsPlate
contact affiliationVanderbilt University
contact emaillars.plate@vanderbilt.edu
lab head
LarsPlate
contact affiliationVanderbilt University
contact emaillars.plate@vanderbilt.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
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